Certificate of Analysis
| Product Name: | Daprodustat |
| Catalog Number: | M8924 |
| CAS Number: | 960539-70-2 |
Physical and Chemical Properties
| Formula: | C19H27N3O6 |
| Molecular Weight: | 393.43 |
| Solubility: | DMSO 16 mg/mL (ultrasonic and warming) |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 99.94% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Daprodustat (GSK1278863) is a novel, first-in-class, orally active inhibitor of hypoxia-induced factor prolyl hydroxylase (HIF-PHI). Reversible inhibition of HIF-PHD activity under normal partial oxygen pressure can temporarily inhibit HIF-α degradation and promote the expression of related hypoxia metabolism genes. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |