Certificate of Analysis
| Product Name: | Cyclosporine A |
| Catalog Number: | M1831 |
| CAS Number: | 59865-13-3 |
Physical and Chemical Properties
| Formula: | C62H111N11O12 |
| Molecular Weight: | 1202.61 |
| Solubility: | DMSO ≥ 45 mg/mL |
| Storage: | 2-8°C, dry, sealed, protect from light |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 100.00% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Cyclosporin A is an immunosuppressant that binds to cyclophilin and inhibits calcineurin with an IC50 of 7 nM. cyclosporin A [CsA] binds to the cyclophilin 18 (Cyp18)-CsA complex. the Cyp18-CsA complex recruits calcium-regulated neurophosphatase (CaN), leading to the blocking of cytokine gene transcription in activated T cells. CsA is a highly specific inhibitor of T-cell activation. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |