Certificate of Analysis


Catalog Number: M5320
Product Name: Crizotinib hydrochloride
CAS Number: 1415560-69-8

Physical and Chemical Properties
Formula: C21H23Cl3FN5O
Molecular Weight: 486.8
Solubility: ≥ 4.6 mg/mL in DMSO
Storage: at -20°C
Chemical Structure: Crizotinib hydrochloride Structure
Analytical Data
HPLC: Shows Min >98% purity
H-NMR: Consistent with structure
Product Information
Description: Crizotinib is inhibitor of the c-Met kinase and the NPM-ALK. Crizotinib inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM). Crizotinib is useful in treatment of anaplastic large-cell lymphoma.
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.