Certificate of Analysis
| Product Name: | BAY 87-2243 |
| Catalog Number: | M4869 |
| CAS Number: | 1227158-85-1 |
Physical and Chemical Properties
| Formula: | C26H26F3N7O2 |
| Molecular Weight: | 525.53 |
| Solubility: | DMSO 20 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 98.86% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | BAY87-2243 is a potent inhibitor of selective hypoxia-inducible facin-1 (HIF-1). Bay87-2243 induces iron death and necrosis in BRAFV600E melanoma cells by inhibiting the mitochondrial respiratory chain, resulting in ROS accumulation, lipid peroxidation, and GSH deletion. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |