Certificate of Analysis
| Product Name: | AZD9291 (Osimertinib) |
| Catalog Number: | M2424 |
| CAS Number: | 1421373-65-0 |
Physical and Chemical Properties
| Formula: | C28H33N7O2 |
| Molecular Weight: | 499.61 |
| Solubility: | DMSO 90 mg/mL (Need warming and ultrasonic) |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 99.50% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Osimertinib (AZD-9291) is an oral, irreversible, and mutant-selective EGFR inhibitor with IC50 of 12.92, 11.44 and 493.8 nM for Exon 19 deletion EGFR, L858R/T790M EGFR, and WT EGFR, respectively. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |