Certificate of Analysis

 

Product Name: Capivasertib (AZD5363)
Catalog Number: M2303
CAS Number: 1143532-39-1

Physical and Chemical Properties
Formula: C21H25ClN6O2
Molecular Weight: 428.92
Solubility: DMSO 100 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: Capivasertib (AZD5363) Structure
Analytical Data
QC Standard: >99%
H-NMR: Consistent with structure
Product Information
Description: Capivasertib (AZD5363) is a potentially first-in-class, orally effective pan-AKT inhibitor with strong inhibition against all three AKT isomers (AKT1/2/3) at an IC50 of 3 nM/8 nM/8 nM. It also showed similar inhibitory effect on P70S6K/PKA and low inhibitory activity on ROCK1/2.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.