Certificate of Analysis

 

Catalog Number: M3569
Product Name: AST-1306
CAS Number: 1050500-29-2

Physical and Chemical Properties
Formula: C24H18ClFN4O2
Molecular Weight: 621.08
Solubility: DMSO 100 mg/mL
Long-term Storage: at -20℃
Chemical Structure: AST-1306 Structure
Analytical Data
HPLC: Shows Min >99% purity
H-NMR: Consistent with structure
Product Information
Description: AST-1306 is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases,
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.