Certificate of Analysis

 

Product Name: Abemaciclib (LY2835219)
Catalog Number: M10347
CAS Number: 1231929-97-7

Physical and Chemical Properties
Formula: C27H32F2N8
Molecular Weight: 506.59
Solubility: DMSO 3 mg/mL (ultrasonic and warming)
Storage: 2-8°C, protect from light, sealed
Chemical Structure: Abemaciclib (LY2835219) Structure
Analytical Data
QC Standard: 100.0%
H-NMR: Consistent with structure
Product Information
Description: Abemaciclib (LY2835219) is a best-in-class, selective and effective dual inhibitor of CDK4 and CDK6, which inhibits CDK4/CDK6 activity with IC50 of 2 nM and 10 nM respectively.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.